EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.147 | Homo sapiens | Q9BRR6 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.147 | Burkitt lymphoma cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.147 | ADP + D-glucose | - |
Homo sapiens | AMP + D-glucose 6-phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.147 | ADP-dependent glucokinase | - |
Homo sapiens |
2.7.1.147 | ADPGK | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.1.147 | malfunction | ADPGK knock-out Ramos BL cells display abated in vitro and in vivo tumour aggressiveness, via tumour-macrophage co-culture, migration and Zebrafish xenograft studies. Perturbed glycolysis and visibly reduced markers of Warburg effect in ADPGK knock-out cells, finally leading to apoptosis. Knock-out cells show repression of MYC proto-oncogene, and up to four-fold reduction in accumulated mutations in translocated MYC | Homo sapiens |
2.7.1.147 | physiological function | the enzyme plays a major role in T-cell activation and induction of Warburg effect | Homo sapiens |