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Literature summary extracted from

  • Tandon, A.; Birkenhagen, J.; Nagalla, D.; Koelker, S.; Sauer, S.W.
    ADP-dependent glucokinase as a novel onco-target for haematological malignancies (2020), Sci. Rep., 10, 13584 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.147 Homo sapiens Q9BRR6
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.147 Burkitt lymphoma cell
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 Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.147 ADP + D-glucose
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 Homo sapiens AMP + D-glucose 6-phosphate
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.147 ADP-dependent glucokinase
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 Homo sapiens
2.7.1.147 ADPGK
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 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.147 malfunction ADPGK knock-out Ramos BL cells display abated in vitro and in vivo tumour aggressiveness, via tumour-macrophage co-culture, migration and Zebrafish xenograft studies. Perturbed glycolysis and visibly reduced markers of Warburg effect in ADPGK knock-out cells, finally leading to apoptosis. Knock-out cells show repression of MYC proto-oncogene, and up to four-fold reduction in accumulated mutations in translocated MYC Homo sapiens
2.7.1.147 physiological function the enzyme plays a major role in T-cell activation and induction of Warburg effect Homo sapiens